The Cardialen unpinning termination (UPT) therapy delivers a sequence of low-energy electrical pulses designed to stop abnormally rapid heart rates. This low-energy therapy is being developed to mitigate the negative effects of current high-energy defibrillators by delivering lower energy, less debilitating treatment for patients with heart arrhythmias. 


UPT therapy is being developed to significantly reduce the negative effects of existing high-energy defibrillators.1

  • Prior attemps to treat Atrial Fibrillation (AF) through implantable defibrillators were successful, but painful shocks proved intolerable for many patients.1

  • Recent studies indicate that high-energy Ventricular Fibrillation (VF) therapies may lead to increased mortality compared to patients receiving fewer shocks or a low-energy therapy.2,3

Early feasibility study data suggest low-energy therapy may treat AF with less energy than typically required with conventional treatments.4.5

CAUTION: Investigational Device. Limited by Federal (United States) law to investigational use only.

  1. Geller, J., Reek, S., Timmermans, C., et al. (2003). Treatment of atrial fibrillation with an implantable atrial defibrillator – long term results. Eur Heart J, 24, 2083-2089. doi:10.1016/j.ehj.2003.09.033.

  2. Moss AJ, Schuger C, Beck CA, et al. (2012). Reduction in Inappropriate Therapy and Mortality through ICD Programming. N Engl J Med. 367(24), 2275-83. doi:10.1056/NEJMoa1211107.

  3. Ruwald AC, Schuger C, Moss AJ, et. al. (2014). Mortality Reduction in Relation to Implantable Cardioverter Defibrillator Programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Circ Arrhythm Electrophysiol. 7:785-792. doi:10.1161/CIRCEP.114.001623.

  4. Ng, F-S. et. al. Painless Atrial Cardioversion using Low-Energy Multistage Electrotherapy: First-in-Man Feasibility Trial; Fu Siong Ng; 2017 Heart Rhythm Society Abstract (C-PO01-21) Heart Rhythm, 2017,14 (5):S103 (Abstr).

  5. Meyers, J, et. al. Low Energy Multistage Electrotherapy for Ventricular Defibrillation in a Canine Model C-PO05-34 Heart Rhythm, 2017,14 (5):S432 (Abstr) .