UNPINNING TERMINATION (UPT) THERAPY
The Cardialen unpinning termination (UPT) therapy delivers a sequence of low-energy electrical pulses designed to stop abnormally rapid heart rates. This low-energy therapy is being developed to mitigate the negative effects of current high-energy defibrillators by delivering lower energy, less debilitating treatment for patients with heart arrhythmias.
UPT therapy is being developed to significantly reduce the negative effects of existing high-energy defibrillators.1
Prior attemps to treat Atrial Fibrillation (AF) through implantable defibrillators were successful, but painful shocks proved intolerable for many patients.1
Recent studies indicate that high-energy Ventricular Fibrillation (VF) therapies may lead to increased mortality compared to patients receiving fewer shocks or a low-energy therapy.2,3
Early feasibility study data suggest low-energy therapy may treat AF with less energy than typically required with conventional treatments.4.5
CAUTION: Investigational Device. Limited by Federal (United States) law to investigational use only.
Geller, J., Reek, S., Timmermans, C., et al. (2003). Treatment of atrial fibrillation with an implantable atrial defibrillator – long term results. Eur Heart J, 24, 2083-2089. doi:10.1016/j.ehj.2003.09.033.
Moss AJ, Schuger C, Beck CA, et al. (2012). Reduction in Inappropriate Therapy and Mortality through ICD Programming. N Engl J Med. 367(24), 2275-83. doi:10.1056/NEJMoa1211107.
Ruwald AC, Schuger C, Moss AJ, et. al. (2014). Mortality Reduction in Relation to Implantable Cardioverter Defibrillator Programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Circ Arrhythm Electrophysiol. 7:785-792. doi:10.1161/CIRCEP.114.001623.
Ng, F-S. et. al. Painless Atrial Cardioversion using Low-Energy Multistage Electrotherapy: First-in-Man Feasibility Trial; Fu Siong Ng; 2017 Heart Rhythm Society Abstract (C-PO01-21) Heart Rhythm, 2017,14 (5):S103 (Abstr).
Meyers, J, et. al. Low Energy Multistage Electrotherapy for Ventricular Defibrillation in a Canine Model C-PO05-34 Heart Rhythm, 2017,14 (5):S432 (Abstr) .